Abcam, ab272658, Anti-DEGA antibody

Size: 100µL
Rabbit Polyclonal DEGA antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human AMIGO2 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AMIGO2 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q86SJ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The DEGA protein also known as DEGA-1 functions mechanically as a transmembrane protein involved in cellular adhesion. It has a mass of approximately 55 kDa and expresses widely in epithelial tissues where cellular interactions requiring adhesion are important for tissue integrity. DEGA is present in various cell types indicating its broad physiological relevance across tissues.
Biological function summary
This protein plays a role in modulating cell adhesion dynamics and contributes to tissue organization and stability. It forms part of adhesion complexes at the cellular surface interacting with cytoskeletal elements. Through these complexes DEGA helps maintain mechanical stability and signaling within epithelial cells making it an important component in tissue maintenance and repair.
Pathways
DEGA participates in cellular adhesion and signaling pathways essential for maintaining epithelial integrity. It interacts with proteins such as E-cadherin a well-known adhesion molecule forming a network that reinforces adhesion. This protein also integrates signals for pathway regulation playing a critical role in maintaining homeostasis in the epithelial layer.
DEGA is linked to epithelial-related conditions such as carcinomas where altered adhesion contributes to disease progression. It interacts with proteins involved in tumorigenesis such as E-cadherin and beta-catenin. The loss or dysfunction of DEGA can lead to disrupted cell adhesion contributing to the invasive characteristics of cancerous cells highlighting its importance in disease pathology.