Abcam, ab272679, Anti-ZNF341 antibody

Size: 100µL
Rabbit Polyclonal ZNF341 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF341 aa 350-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF341 aa 350-450. The exact immunogen used to generate this antibody is proprietary information.Q9BYN7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF341 also known as zinc finger protein 341 is a transcription factor characterized by its zinc finger motifs which are essential for binding to DNA. It has an approximate molecular mass of 98 kDa. Researchers have observed ZNF341 expression primarily in lymphoid tissues suggesting a role in immune function. The protein engages directly with DNA to regulate gene expression impacting transcriptional activity which influences various cellular processes.
Biological function summary
The function of ZNF341 involves regulating the immune system. This protein influences the transcriptional regulation of genes linked to immune responses and development. ZNF341 does not typically form part of a larger protein complex instead acting independently to facilitate transcriptional activation or repression in immune cells. Its activity impacts the production of cytokines and antibodies which are important for mounting effective immune responses.
Pathways
ZNF341 plays significant roles in the immune response pathways such as the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway and the NF-kB signaling pathway. The JAK-STAT pathway involves various proteins including STAT3 and STAT5 which interact with ZNF341 to mediate gene expression involved in cell proliferation and defense mechanisms. ZNF341 also engages components of the NF-kB pathway to regulate inflammatory responses highlighting its importance in immune function.
ZNF341 is closely related to immunodeficiencies and autoimmune diseases. Hypomorphic mutations in ZNF341 can lead to a combined immunodeficiency characterized by a weakened immune system's inability to respond effectively to infections. The protein connects to the pathogenesis of these diseases through its interaction with other immune-related proteins like STAT3. Furthermore ZNF341's involvement in the regulation of immune responses can link it to autoimmune diseases where the overactive or misguided immune response targets the body's own tissues.