Abcam, ab272891, Anti-P2Y2 antibody

Size: 100µL
Rabbit Polyclonal P2Y2 antibody. Suitable for ICC/IF, WB and reacts with Human, Recombinant fragment samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human P2RY2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human P2RY2. The exact immunogen used to generate this antibody is proprietary information.P41231

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The P2Y2 receptor also known as P2RY2 or purinergic receptor P2Y G-protein coupled 2 is a receptor protein with a molecular mass of approximately 41 kDa. It belongs to the family of G-protein coupled receptors (GPCRs) and responds to extracellular nucleotides such as ATP and UTP. P2Y2 is mainly expressed in tissues including the lung kidney heart and immune cells. It plays a significant role in mediating cellular responses to external stimuli through nucleotide binding.
Biological function summary
The P2Y2 receptor serves key functions in cellular signaling especially in processes like inflammation and tissue repair. It acts by coupling with G-protein complexes to initiate intracellular signaling cascades. Activation of P2Y2 can lead to the release of calcium from intracellular stores and activation of protein kinase pathways contributing to the regulation of cell proliferation migration and cytokine release. This receptor does not exist as part of a larger protein complex but interacts dynamically with other cellular machinery to regulate physiological functions.
Pathways
P2Y2 receptor engagement triggers responses in the phosphoinositide pathway and the mitogen-activated protein kinase (MAPK) pathway. These pathways modulate cell growth and stress responses. P2Y2 receptor activity is interlinked with other receptors like P2Y1 and P2Y4 sharing similar downstream signaling effects. This interaction system allows for integrated cellular responses to various extracellular nucleotide concentrations making it critical for coordinated cellular responses.
Altered P2Y2 expression or function associates with conditions like cystic fibrosis and atherosclerosis. In cystic fibrosis abnormal P2Y2 activity impacts chloride ion transport and mucus clearance due to its role in epithelial cell signaling. During atherosclerosis P2Y2 receptor modulates inflammatory response and vascular remodelling contributing to plaque formation. Its interaction with proteins such as CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) in cystic fibrosis and integrins in atherosclerosis exemplifies its involvement in disease mechanisms.