Abcam, ab273125, Anti-IRR antibody [EPR24776-127]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal IRR antibody. Suitable for IP, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24776-127,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Insulin Receptor-Related Receptor (IRR) also called INSRR is a receptor tyrosine kinase that is linked structurally to the insulin receptor. This protein has a molecular mass of about 140 kDa. IRR expresses in tissues such as the kidney lung and stomach. It functions mainly as a pH sensor playing a role in regulating cellular responses to extracellular pH changes. Through its intrinsic kinase activity IRR phosphorylates specific substrates upon ligand binding initiating downstream signaling events.
Biological function summary
IRR acts in a manner analogous to other receptor tyrosine kinases but is unique in its role as a pH sensor impacting various physiological processes. It does not usually form part of larger protein complexes but influences cellular homeostasis and adaptive responses to acidic conditions. Its activity may affect cellular growth and differentiation. Researchers have identified that IRR contributes to maintaining the pH balance in tissues where it is present which implies its importance in controlling basic cellular functions.
Pathways
The IRR participates in signaling pathways that monitor and regulate pH homeostasis and related metabolic responses. It connects with the MAPK/ERK pathway which influences cell proliferation and stress responses. This connection links IRR and MAPK/ERK to processes essential for cellular adaptation to changing pH conditions. The presence of proteins like Akt which also has roles in the pathways involving insulin receptor signals suggests IRR might have related but distinct signaling functions.
The understanding of IRR's role relates to conditions such as cancer and metabolic acidosis. Changes in its activity may influence cancer progression due to its ties with cell proliferation pathways. Abnormal IRR signaling potentially impacts acidosis-related metabolic dysfunctions where IRR's regulatory action on pH becomes critical. In these contexts proteins like the insulin receptor may share overlapping functionalities with IRR as both are receptor tyrosine kinases although IRR’s specific disease links remain less characterized.