Abcam, ab273384, Buparlisib (BKM120)

Size: 5mg / 25mg
MW 410.4 Da, Purity >95%. Potent class I PI3K inhibitor, blocking both p110α and p110β (IC₅₀ = 52 nM and 166 nM, respectively) in vitro . At 5 μM, prevents the growth of assorted cancer cell lines and inhibits tumor growth in vivo . Reduced effect against class III PI3K Vps34 and mammalian target of rapamycin (mTOR).
Key facts
CAS number:944396-07-0,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:410.4 Da,
Molecular formula:C18H21F3N6O2,
PubChem:16654980,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mMSoluble in ethanol to 25 mM,
Biochemical name:Buparlisib,
Biological description:Potent class I PI3K inhibitor, blocking both p110α and p110β (IC₅₀ = 52 nM and 166 nM, respectively) in vitro. At 5 μM, prevents the growth of assorted cancer cell lines and inhibits tumor growth in vivo. Reduced effect against class III PI3K Vps34 and mammalian target of rapamycin (mTOR).,
Canonical smiles:C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4,
InChi:InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23),
InChiKey:CWHUFRVAEUJCEF-UHFFFAOYSA-N,
IUPAC Name:5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2619 NVP-BKM120. 2619-25 is the same size as the 25 mg size of ab273384.
Protect from air.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store in the dark