Abcam, ab273523, PF-573228

Size: 10mg / 50mg
MW 491.5 Da, Purity >98%. Potent and selective FAK inhibitor (IC 50 = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells (IC 50 = 30–100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.
Key facts
CAS number:869288-64-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:491.5 Da,
Molecular formula:C22H20F3N5O3S,
PubChem:11612883,
Nature:Synthetic,
Solubility:Soluble in DMSO to 75 mM,
Biochemical name:3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone,
Biological description:Potent and selective FAK inhibitor (IC50 = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells (IC50 = 30–100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.,
Canonical smiles:CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4,
InChi:InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30),
InChiKey:HESLKTSGTIBHJU-UHFFFAOYSA-N,
IUPAC Name:6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2819 PF-573228. 2819-50 is the same size as the 50 mg size of ab273523.
Protect from air.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark