Abcam, ab273600, Ganetespib (STA-9090)

Size: 5mg / 25mg
MW 364.4 Da, Purity >98%. Potent Hsp90 inhibitor (IC 50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC 50 of 43 nM.
Key facts
CAS number:888216-25-9,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:364.4 Da,
Molecular formula:C20H20N4O3,
PubChem:135564985,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:Ganetespib,
Biological description:Potent Hsp90 inhibitor (IC50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC50 of 43 nM.,
Canonical smiles:CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O,
InChi:InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27),
InChiKey:RVAQIUULWULRNW-UHFFFAOYSA-N,
IUPAC Name:3-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C