Abcam, ab273674, Anti-LAT2 antibody [UMAB70] - BSA and Azide free

Size: 100µg
Mouse Monoclonal LAT2 antibody. Carrier free. Suitable for Protein Microarray ChIP, IHC-P, WB, ICC/IF and reacts with Purified native protein - Human, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLC7A8.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:UMAB70,
Isotype:IgG1,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-P, Protein Microarray ChIPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SLC7A8.Q9UHI5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from TCS., Storage buffer-pH: 7.3Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LAT2 also known as Linker for Activation of T cells 2 is a cytoplasmic adaptor protein with a molecular mass of approximately 38 kDa. LAT2 plays an important role in intracellular signaling and is widely expressed in immune system cells especially T cells mast cells and platelets. This protein functions as a scaffold providing binding sites for several signaling molecules involved in immune cell activation.
Biological function summary
LAT2 contributes significantly to immune system responses. It forms complexes with proteins such as SLP-76 to facilitate signal transduction. LAT2 becomes phosphorylated upon activation which recruits multiple effector molecules and serves as a platform for further signaling processes. This mechanism enhances the transmission of activation signals that lead to immune cell proliferation and differentiation.
Pathways
Proteins interacting with LAT2 participate in the T cell receptor (TCR) signaling pathway and FcεRI signaling in mast cells. LAT2 anchors important signaling molecules within these pathways including ZAP-70 and PLCγ1 which further propagate the signal cascade necessary for immune responses. The LAT2-SLP-76 complex helps coordinate the assembly of various intracellular signaling proteins in these pathways which is vital for effective cellular functions.
Defects or alterations in LAT2 function can result in immune system-related conditions such as immunodeficiencies and autoimmune disorders. Abnormal LAT2 signaling is linked to diseases like systemic lupus erythematosus where T cell signaling becomes dysregulated. Further LAT2 interacts with proteins such as Syk involved in other immune disorders highlighting its importance in maintaining immune system balance.