Abcam, ab274417, Anti-Neurturin antibody [EPR23301-10]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Neurturin antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23301-10,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neurturin also called NRTN is a neurotrophic factor belonging to the glial cell line-derived neurotrophic factor (GDNF) family. It is a protein weighing approximately 23 kDa. Neurturin promotes the survival of neurons and is mainly active in the central nervous system and peripheral nervous system. It is expressed in various tissues including the brain spinal cord and organs such as the liver and pancreas.
Biological function summary
Neurturin supports the maintenance and function of many neuronal populations. It partners with the RET receptor tyrosine kinase and the GFRα2 co-receptor to form a receptor complex that mediates its signaling. This interaction is important for neuronal differentiation and survival especially in dopamine-producing neurons and parasympathetic neurons. Neurturin's activity ensures proper nerve development and the maintenance of effective neuronal networks.
Pathways
Several important elements are involved with neurturin function. It plays a role in the MAPK/ERK and the PI3K/Akt signaling pathways both of which are essential for cell survival and growth. In these pathways neurturin acts alongside proteins like GDNF and RET helping to transmit cellular signals that either promote cell survival or modulate neuronal function depending upon the cellular context.
Research links neurturin to conditions like Parkinson’s disease and Hirschsprung's disease. In Parkinson’s disease the decrease in dopaminergic neurons correlates with malfunction or decreased activity of neurturin and its associated receptors like RET. Similarly insufficient signaling involving neurturin and its receptor complex might contribute to the development of Hirschsprung's disease a disorder related to the absence of nerve cells in the colon.