Abcam, ab274418, Anti-PCSK2 antibody [EPR23578-19]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal PCSK2 antibody. Suitable for mIHC, ICC/IF, WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23578-19,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:mIHC, IHC-P, Flow Cyt (Intra), ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PCSK2 also known as proprotein convertase 2 is an enzyme with a molecular mass of approximately 75 kDa. It functions by processing various precursor proteins into their active forms. PCSK2 belongs to the family of serine proteases and is mainly expressed in endocrine and neuroendocrine tissues including the pituitary gland kidneys and pancreas. This protein is important in the maturation of peptide hormones and neuropeptides impacting physiological functions.
Biological function summary
PCSK2 is responsible for activating various prohormones into their active hormone counterparts. It accomplishes this by cleaving specific sites on precursor proteins. PCSK2 does not operate as part of a complex but independently participates in proteolytic processing essential for proper hormone functioning. This enzyme's activity is critical for the synthesis of key hormones like insulin and glucagon which regulate glucose metabolism.
Pathways
PCSK2 is a significant part of hormone processing pathways. Specifically it contributes to the insulin-processing pathway which is important for energy regulation and homeostasis. PCSK2 works closely with related proteins such as PCSK1 (proprotein convertase 1) in the cleavage of precursor forms of various hormones. The coordinated action of these enzymes ensures the production of bioactive hormones required for normal metabolic functions.
PCSK2 is associated with conditions like diabetes and obesity due to its role in processing hormones that regulate metabolism. Dysregulation or mutations in the PCSK2 gene can disrupt insulin and glucagon maturation leading to imbalances in blood sugar levels. Additionally variations in PCSK2 may influence fat storage and energy expenditure contributing to obesity. The interaction between PCSK2 and insulin-related pathways highlights its importance in maintaining metabolic health.