Abcam, ab276896, Recombinant mouse IFNA14 protein (His tag)

Size: 100µg
Recombinant mouse IFNA14 protein (His tag) is a Full Length protein, in the 24 to 189 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
Key facts
Purity:>90% SDS-PAGE,
Endotoxin level:< 1 EU/µg,
Expression system:HEK 293 cells,
Tags:His tag C-Terminus,
Applications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Measured in antiviral assay using L929 cells infected with vesicular stomatitisvirus (VSV).The ED50 for this effect is typically 5-40 pg/mL.,
Animal free:No,
Carrier free:No,
Storage buffer:pH: 7.4Constituents: 100% PBS

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IFNA14 also known as Interferon Alpha-14 is a low molecular weight protein weighing approximately 19.3 kDa. It belongs to the type I interferon family and functions as a cytokine. IFNA14 is primarily expressed in leukocytes where it exerts its effects on various immune responses. This protein contributes to the antiviral boundaries of cells by binding to specific cell-surface receptors.
Biological function summary
IFNA14 plays an essential role in the immune system response to viral infections. It interacts with the type I interferon receptor complex to activate transcription of interferon-stimulated genes which help to mediate antiviral effects. IFNA14 signals through the JAK-STAT pathway ultimately leading to an increased expression of MHC class I antigens and enhanced immune recognition. Its activity aids in the coordination of the immune system's efforts to combat viral pathogens.
Pathways
IFNA14 is integral to the interferon signaling pathway and plays a part in the innate immune response pathway. These pathways involve a cascade of proteins including JAK1 and STAT2 which mediate its signal transduction. The activation of these pathways leads to transcriptional changes necessary for an effective antiviral state and modulation of the immune response.
IFNA14 has connections with viral infections like Hepatitis C and systemic lupus erythematosus (SLE). Its dysregulation or overexpression can lead to an inappropriate immune response contributing to the pathogenesis of these conditions. The relationship between IFNA14 and other interferon-induced proteins such as IRF7 highlights its significance in disease progression and points to potential therapeutic targets.