Abcam, ab277179, Human GPR137 knockout U-2 OS cell line

Size: 1000000Cells / vial / 2 x 1000000Cells / vial
GPR137 KO cell line available to order. KO validated by Next Generation Sequencing. Free of charge wild type control available. Knockout achieved by CRISPR/Cas9 X = 1 bp deletion Frameshift: 100%. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:U-2 OS,
Species or organism:Human,
Tissue:Bone,
Form:LiquidSee storage information,
Knockout validation:Next Generation Sequencing,
Mutation description:Knockout achieved by CRISPR/Cas9 X = 1 bp deletion Frameshift: 100%,
Disease:Osteosarcoma

Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-GPR137, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Next Generation Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions--196°C, -80°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR137 also known as G protein-coupled receptor 137 is a transmembrane protein with a mass of approximately 36 kDa. It belongs to the G protein-coupled receptor superfamily which is known for transmitting signals from outside the cell to the interior. GPR137 is mostly expressed in various tissues including brain kidney and liver highlighting its broad physiological roles. Due to its structure and signaling capabilities GPR137 plays a significant role in intracellular communication and cellular responses.
Biological function summary
Researchers identify GPR137 as a protein involved in modulating cellular growth survival and differentiation. It functions as a critical part of cellular signaling networks often forming complexes with other receptor proteins to enhance or inhibit signaling pathways. In some studies GPR137 has shown associations with cellular processes like autophagy and apoptosis indicating its importance in maintaining cellular homeostasis. Its expression in multiple tissues suggests it may perform diverse functions depending on the tissue type.
Pathways
Several studies have linked GPR137 to the mTOR signaling and Wnt pathways. These pathways are essential for cell growth proliferation and differentiation. GPR137 interacts with components like mTORC1 in the mTOR signaling pathway which influences protein synthesis and energy metabolism. In the Wnt pathway GPR137 may work alongside proteins like β-catenin contributing to the regulation of gene expression. Understanding its role in these pathways can provide valuable insight into its functions and interactions with other cellular components.
GPR137 has connections to cancer and neurodegenerative diseases. Changes in its expression or function can influence the progression of tumors by affecting cell proliferation and death. Additionally its involvement in the mTOR and Wnt pathways suggests a role in neurodegenerative diseases where these pathways are disrupted. GPR137 can interact with proteins like p53 in cancer linking it to mechanisms of cell cycle regulation and apoptosis. Its relationship with these diseases positions GPR137 as a potential target in therapeutic strategies.