Abcam, ab277535, Anti-MAG/GMA antibody [EPR24276-125] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal MAG/GMA antibody. Carrier free. Suitable for ICC/IF, IP, WB, IHC-Fr, IHC-P and reacts with Rat, Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24276-125,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, IHC-Fr, ICC/IF, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab277535 is the carrier-free version of
ab277524
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAG (Myelin-Associated Glycoprotein) sometimes referred to as 'MAG protein' 'MAG RAT' or 'MAG/GMA' weighs approximately 100 kDa. This protein is prominently expressed in the central and peripheral nervous systems. MAG localizes to the periaxonal region of myelinated axons making it essential for proper neuronal function. It plays an important role in maintaining the stability and structure of myelin sheaths which are important for the efficient transmission of nerve impulses.
Biological function summary
This protein acts as an adhesion molecule that contributes to the myelination process. It exists as part of a molecular complex that interacts with other oligodendrocyte and Schwann cell proteins. This interaction is important for nerve regeneration and the expansion of the myelin sheath during development and repair. MAG also assists in signaling between axons and glial cells improving cellular communication and myelin integrity.
Pathways
MAG significantly impacts pathways such as the Nogo receptor which is associated with inhibiting axonal growth and regeneration. MAG interacts with the NOGO protein and other members of the Nogo receptor signaling pathway where it functions to regulate neuronal growth and regeneration. Furthermore MAG's interplay with NOGO receptor components contributes to limiting excessive sprouting of axons balancing growth and stability of the nervous system.
MAG is notably linked to neuropathies and multiple sclerosis. In neuropathies abnormal MAG expression can disrupt nerve conduction and lead to demyelinating conditions. Multiple sclerosis sees extensive involvement of MAG where its malfunction or reduced expression associates with the failure of remyelination processes. Additionally MAG's connection with proteins such as NOGO and other myelin-associated inhibitors implicates its role in the pathology of these disorders offering potential targets for therapeutic interventions.