Abcam, ab277626, Anti-PEA15 antibody [4D2]

Size: 50µL
Mouse Monoclonal PEA15 antibody. Suitable for IHC, WB and reacts with Rat, Mouse, Cow samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PEA15.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4D2,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Rat, Cow,
Applications:IHC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PEA15.Q15121

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from Tissue Culture supernatant., Storage buffer-Preservative: 0.03% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PEA15 also known as phosphoprotein enriched in astrocytes 15 or PED is a multifunctional protein weighing around 15 kDa. Mechanically PEA15 acts as a death effector domain (DED)-containing protein that modulates diverse cellular processes by binding to and inhibiting other DED-containing proteins. This protein shows wide expression notably in the central nervous system including the brain where it exerts critical roles in signaling networks.
Biological function summary
PEA15 plays pivotal roles in promoting cellular survival and regulating apoptosis within various cell types. It operates by modulating pathways like apoptosis and cell proliferation often forming complexes with other DED-containing proteins such as FADD and caspase-8. By interacting with these proteins PEA15 can maintain cellular stability and manage stress responses illustrating its significant contribution to cellular homeostasis.
Pathways
PEA15 is integral in mediating the extracellular signal-regulated kinase (ERK) and MAP kinase pathways. As PEA15 binds to ERK1/2 it retains these kinases in the cytoplasm impeding their translocation to the nucleus and therefore affecting the transcription of target genes. Furthermore its interactions with Ras-related proteins indicate its involvement in the regulation of cell growth and differentiation showing its broad influence on cellular signaling cascades.
PEA15 correlates with neurological conditions including Alzheimer's disease and gliomas. In Alzheimer's disease PEA15 modulates neuroinflammation and amyloid precursor protein processing collaborating with proteins such as tau and amyloid-beta. In gliomas alterations in PEA15 expression influence tumor progression and treatment susceptibility highlighting important intersections with oncogenic factors like EGFR and PTEN. These associations spotlight PEA15 as a potential therapeutic target in both neurodegenerative and cancerous disorders.