Abcam, ab2783, Anti-Calcium Pump PMCA4 ATPase antibody [JA9]

Size: 100µg
Mouse Monoclonal Calcium Pump PMCA4 ATPase antibody. Suitable for IHC-P, ICC, Flow Cyt, WB and reacts with Human, Cow samples. Cited in 28 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human ATP2B4.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:JA9,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human, Cow,
Applications:WB, IHC-P, ICC, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human ATP2B4.P23634,
Specificity:This antibody is specific to the PMCA4 isoform.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Calcium Pump PMCA4 ATPase also known as ATP2B4 is a plasma membrane calcium ATPase responsible for the extrusion of Ca2+ ions from the cell. It plays an essential role in maintaining calcium homeostasis within eukaryotic cells. PMCA4 weighs approximately 134 kDa and is expressed in various tissues including the heart brain and kidney. The protein actively transports Ca2+ out of the cell using energy obtained from ATP hydrolysis.
Biological function summary
PMCA4 regulates intracellular calcium levels impacting processes such as muscle contraction neurotransmitter release and cell signaling. PMCA4 does not function as part of a larger protein complex but interacts with calmodulin which modulates its activity. Calmodulin binding activates PMCA4 increasing its capability to efflux Ca2+ and maintain cellular calcium balance.
Pathways
The calcium pump PMCA4 ATPase plays a critical role in the calcium signaling pathway and the regulation of cardiac rhythm. It helps control Ca2+ concentration within the cell affecting proteins like calcineurin that respond to calcium fluctuations. PMCA4 also interrelates with the sodium-calcium exchanger integrally involved in cardiac muscle contraction and relaxation.
PMCA4 has been linked to conditions such as heart failure and certain neurological disorders. Abnormal expression or function of PMCA4 can dysregulate calcium levels contributing to cardiac arrhythmias. Additionally altered PMCA4 activity can affect synaptic function connecting it indirectly to conditions like schizophrenia. Its interaction with proteins like alpha-synuclein implicated in neurological disorders further highlights PMCA4's relevance in disease states.