Abcam, ab278556, Anti-INPPL1/SHIP-2 (phospho Y1135) antibody [Ship2Y1135-1D2]

Size: 20µL / 100µL
Rabbit Recombinant Monoclonal INPPL1/SHIP-2 phospho Y1135 antibody. Suitable for Flow Cyt and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human INPPL1 phospho Y1135.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:Ship2Y1135-1D2,
Isotype:IgG,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human INPPL1 phospho Y1135. The exact immunogen used to generate this antibody is proprietary information.O15357

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
INPPL1 also known as SHIP-2 (Src homology 2 domain containing inositol 5-phosphatase 2) participates in the regulation of intracellular signaling pathways by dephosphorylating phosphatidylinositol 345-trisphosphate (PIP3). It acts as a phosphatase with a molecular mass of approximately 145 kDa. SHIP-2 is expressed in various tissues including heart brain skeletal muscle and lung. SHIP-2 influences cell growth survival and motility through its enzymatic activity that constrains the levels of PIP3.
Biological function summary
SHIP-2 plays a role in modulating cellular processes like insulin signaling and endocytosis. It acts as a negative regulator counteracting PIP3 accumulation which affects downstream signaling pathways such as Akt. SHIP-2 also integrates into larger protein complexes that contribute to its regulatory functions. These complexes facilitate interactions with multiple cell surface receptors and adaptors emphasizing its role in fine-tuning cell responses.
Pathways
SHIP-2 is an essential component in the insulin signaling and phosphoinositide pathways. It interacts closely with other proteins such as PI3K (phosphoinositide 3-kinase) and PTEN (phosphatase and tensin homolog). In the insulin signaling pathway SHIP-2 modulates the availability of PIP3 impacting the activity of Akt and by extension influence metabolic processes. In the phosphoinositide pathway it harmonizes with PTEN to maintain cellular homeostasis and signaling balance.
SHIP-2 is linked to metabolic diseases like Type 2 Diabetes and obesity. Its regulatory function in insulin signaling positions it as an important player in insulin resistance. Aberrations in SHIP-2 activity can lead to disrupted glucose homeostasis and contribute to the development of these conditions. In the case of insulin signaling disorders SHIP-2's interaction with proteins like IRS-1 (insulin receptor substrate 1) highlights its importance in managing cellular sensitivity to insulin emphasizing its therapeutic potential in metabolic diseases.