Abcam, ab278634, APC Anti-HCLS1 (phospho Y397) antibody [HS1Y397-F12]

Size: 10Test / 100Test
Rabbit Recombinant Monoclonal HCLS1 phospho Y397 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human HCLS1 phospho Y397.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HS1Y397-F12,
Isotype:IgG,
Light chain type:kappa,
Conjugation:APC,
Excitation/Emission:Ex: 650nm, Em: 660nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HCLS1 phospho Y397. The exact immunogen used to generate this antibody is proprietary information.P14317

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 0.2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The hematopoietic cell-specific Lyn substrate 1 commonly known as HCLS1 or HS1 is a cytoskeletal protein involved in cell signaling. It has a molecular mass of approximately 75 kDa and is expressed predominantly in hematopoietic cells such as lymphocytes and myeloid cells. HCLS1 functions as an adaptor protein playing an important role in the reorganization of the actin cytoskeleton which is critical for cell motility and morphology.
Biological function summary
The protein is important for signal transduction processes in immune cells particularly during the immune response. HCLS1 becomes phosphorylated upon cell activation allowing it to associate with other signaling proteins. It forms complexes with various partners like Lyn kinase and other SH2-containing proteins facilitating cytoskeletal rearrangement and cellular interactions necessary for effective immune function.
Pathways
HCLS1 is involved in key signaling pathways such as the B-cell receptor (BCR) and T-cell receptor (TCR) signaling pathways. In these pathways it works alongside proteins like SLP-76 and Vav to propagate signals that lead to cellular activation and differentiation. HCLS1's ability to bind and interact with proteins in these pathways highlights its role in orchestrating cellular immune responses.
HCLS1 has been implicated in certain autoimmune conditions and cancers including chronic lymphocytic leukemia (CLL) and systemic lupus erythematosus (SLE). In these contexts aberrant expression or activity of HCLS1 can disrupt normal immune signaling leading to pathological conditions. Additionally its interaction with proteins such as Bcl-2 in CLL suggests a role in apoptosis regulation further linking HCLS1 to disease progression and treatment response.