Abcam, ab280199, Anti-Glutamate receptor 4 antibody [EPR24283-69]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal GluA4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24283-69,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody weakly cross-reacts with Human GRIA1 but does not cross-react with Human GRIA2 and GRIA3.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Glutamate receptor 4 also known as GluR4 or AMPA receptor 4 is an ionotropic glutamate receptor subunit. This protein has approximately 100 kDa molecular weight. Structurally GluR4 functions as a ligand-gated ion channel that selectively conducts sodium and potassium ions across the neuronal cell membrane. It is typically expressed in the central nervous system with a higher concentration in cerebellar Purkinje cells hippocampal pyramidal neurons and other areas involved in synaptic transmission. This receptor plays a fundamental role in mediating fast excitatory synaptic transmission.
Biological function summary
GluR4 facilitates the fast excitatory neurotransmission by binding to the neurotransmitter glutamate. It forms part of the AMPA receptor complex which consists of four subunits that assemble to create a functional receptor. By enabling rapid and precise control over synaptic signaling GluR4 participates importantly in processes like synaptic plasticity a cellular mechanism for learning and memory. The receptor's dynamic regulation of ion flow into the neuron underpins its role in shaping the physiological response to excitatory stimuli.
Pathways
GluR4 plays an important role within the glutamatergic synapse pathway. It interacts directly with other proteins such as stargazin which assists in the trafficking and anchoring of AMPA receptors at synaptic sites. GluR4 is also involved in the long-term potentiation pathway a mechanism for strengthening synapses that is vital for learning. When glutamate opens the channel GluR4 allows the influx of sodium ions which can lead to depolarization and trigger downstream signaling events. This receptor works in conjunction with NMDA receptors to modulate synaptic strength and connectivity.
GluR4 has been implicated in neurological conditions such as epilepsy and neurodegenerative diseases like Alzheimer's. In epilepsy dysregulation of glutamate receptors including GluR4 can lead to abnormal neuronal excitability and seizures. Another connection exists with amyloid beta protein found in Alzheimer's disease which can disrupt glutamate receptor function leading to synaptic dysfunction. Investigating these associations helps to understand the pathological mechanisms and potential therapeutic approaches targeting GluR4-related pathways.