Abcam, ab280576, Anti-IMPA2 antibody [EPR23668-64] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal IMPA2 antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse, Rat, Transfected cell lysate - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23668-64,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab280576 is the carrier-free version of
ab256410
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IMPA2 also known as Inositol Monophosphatase 2 is an enzyme with a mass of approximately 29 kDa. This protein is expressed predominantly in the brain particularly in regions such as the cerebellum and cerebral cortex. IMPA2 catalyzes the dephosphorylation of inositol monophosphate to free inositol an essential step in the phosphatidylinositol signaling pathway. This enzyme plays a significant role in maintaining inositol and inositol-derived compounds important for cellular functions.
Biological function summary
IMPA2 influences cellular processes by managing inositol phosphate recycling and inositol availability. This enzyme does not typically function as part of a larger protein complex. Its activity helps control the levels of inositol in cells impacting signaling pathways that rely on phosphatidylinositol and its derivatives. Through this regulation IMPA2 supports functions like cell growth and survival indirectly affecting neurotransmission and hormone signaling.
Pathways
IMPA2 assumes a central role in the phosphatidylinositol signaling pathway which influences a variety of cellular responses. It interacts closely with the phosphoinositide pathway sharing a relationship with proteins like G-protein coupled receptors and protein kinase C. The enzyme's activity ensures the continuous functioning of these pathways by supplying inositol an important molecule that these proteins need for activation and signaling transmission.
Researchers have linked IMPA2 to bipolar disorder and schizophrenia. Reduced or altered activity of IMPA2 might contribute to imbalance in inositol signaling which is a hypothesis in the pathophysiology of these psychiatric conditions. The protein shows connections to other molecules involved in these disorders such as glycogen synthase kinase-3 (GSK3) which plays a role in mood regulation and neuroplasticity. Understanding the role of IMPA2 in these diseases could offer insights into potential therapeutic approaches.