Abcam, ab281934, Anti-CXCR6 antibody [EPR24686-113] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CXCR6 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24686-113,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab281934 is the carrier-free version of
ab273116
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CXCR6 also known as CD186 or BONZO is a chemokine receptor that belongs to the larger family of G protein-coupled receptors. This receptor has a molecular weight of approximately 45 kDa. CXCR6 gets expressed on various leukocytes including T-cells and natural killer cells. This expression profiles CXCR6 as essential in the immune system where its occupation involves directing cell movement via chemotaxis a process integral for normal immune surveillance and inflammatory response.
Biological function summary
CXCR6 critically orchestrates the interactions between T-cells and antigen-presenting cells within tissues. By engaging its ligand CXCL16 CXCR6 helps mediate cell adhesion and migration. This receptor works as part of an immune complex influencing the migration and retention of immune cells at sites of inflammation. The presence of CXCR6 enhances tissue-specific homing which is vital for localized immune responses.
Pathways
CXCR6 plays a significant role in the chemokine signaling pathway. This pathway leads immune cells to sites of inflammation or infection. Moreover CXCR6 interacts closely with other chemokine receptors such as CCR5. These receptor interactions ensure efficient communication and coordination in cell trafficking across immune environments all of which are critical for proper immune function.
CXCR6 has a known association with diseases like HIV and certain forms of cancer. CXCR6 can act as a co-receptor for the entry of some HIV strains into cells linking it to viral pathogenesis. In the context of cancer CXCR6 and its ligand CXCL16 have connections with tumor cell migration and metastasis. The interaction of CXCR6 with proteins like CXCL16 creates a microenvironment that can either suppress or promote tumor progression depending on the context.