Abcam, ab281949, Anti-Influenza A H1N1 hemagglutinin antibody [10]

Size: 50µL
Rabbit Recombinant Monoclonal Hemagglutinin antibody. Carrier free. Suitable for WB and reacts with Influenza A virus (A/California/14/2009(H1N1)) samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:10,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Influenza A virus (A/California/04/2009(H1N1)),
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:**Specificity**H1N1 Hemagglutinin/HA **No cross-reactivity in ELISA with** H1N1 (A/Brisbane/59/2007) HA H1N1 (A/Brevig Mission/1/1918) HA H5N1 (A/Anhui/1/2005) HA H5N1 (A/Anhui/1/2005) HA2 Sub-unit H5N1 (A/turkey/Turkey/1/2005) HA H5N1 (A/bar-headed goose/Qinghai/14/2008) HA H5N1 (A/Indonesia/5/2005) HA H5N1 (A/Viet Nam/1203/2004) HA H3N2 (A/Brisbane/10/2007) HA Influenza B (B/Florida/4/2006) HA

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Influenza A H1N1 hemagglutinin commonly referred to as H1N1 hemagglutinin is a glycoprotein found on the surface of the influenza virus. This protein with a mass of about 76 kDa enables the virus to attach and fuse with host cells in the respiratory tract. Hemagglutinin is expressed on the viral envelope allowing it to bind to sialic acid receptors on host cells facilitating viral entry through endocytosis. It is a critical component of the viral life cycle and an important target for immune response.
Biological function summary
The H1N1 hemagglutinin plays a significant role in viral infectivity and spread. It exists as a homotrimer complex on the virus surface which undergoes conformational changes to mediate membrane fusion. This protein is also a major antigen that elicits immune responses leading to the production of H1N1 flu antibodies. Importantly the antigenic properties of hemagglutinin drive the need for seasonal flu vaccines as variations in its structure such as those seen in the H1N1 Brisbane strain can affect vaccine efficacy.
Pathways
H1N1 hemagglutinin functions within the viral entry and replication pathways. During infection it works alongside neuraminidase another surface protein to allow proper viral release from infected cells. The interaction between hemagglutinin and cellular sialic acids is important for initiating the viral replication cycle. These interactions mark the beginning of the RIG-I signaling pathway which triggers innate immune responses against the virus.
H1N1 hemagglutinin is linked directly to influenza A infections such as the H1N1 flu which can lead to severe respiratory illness. This protein's variability is associated with pandemics highlighting its importance in disease spread and immune evasion. Changes in the hemagglutinin structure such as those observed in the H1N1 swine flu can cause shifts in virus infectivity. Additionally hemagglutinin interacts with host proteins during infection including pattern recognition receptors which detect viral components and initiate immune defense mechanisms.