Abcam, ab281950, FITC Anti-H7N9 Hemagglutinin antibody [002]

Size: 100Test
Rabbit Recombinant Monoclonal H7N9 Hemagglutinin antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Transfected cell line - H7N9 subtype samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:002,
Isotype:IgG,
Conjugation:FITC,
Excitation/Emission:Ex: 495nm, Em: 519nm,
Carrier free:No,
Reacts with:H7N9 subtype,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.1% Sodium azideConstituents: 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
H7N9 Hemagglutinin also known simply as HA is a glycoprotein important for the entry of the influenza A virus into host cells. It facilitates viral attachment to host cell receptors by binding to sialic acid residues which triggers endocytosis and eventual viral fusion with the host membrane. H7N9 Hemagglutinin has a molecular mass of approximately 75 kDa. It is expressed on the surface of the viral envelope and undergoes a conformational change which is pH-dependent required for fusion with host cell membranes.
Biological function summary
Hemagglutinin plays an essential role in viral infectivity and propagation. As part of the influenza virus surface glycoproteins complex along with neuraminidase it not only aids in viral entry but also influences the immune recognition by the host organism. Hemagglutinin's structure is an important determinant of host specificity and antigenic variation which affects how the immune system identifies and responds to viral infections making it important in immune evasion.
Pathways
H7N9 Hemagglutinin participates in viral entry processes and immune response pathways including antigen processing and presentation. It is closely associated with sialic acid metabolism as it determines the binding specificity and efficiency to different host cells. Its actions are often linked to other viral proteins like neuraminidase which assists in the release of new viral particles albeit with a contrasting function of cleaving sialic acid residues from glycoproteins.
H7N9 Hemagglutinin is associated mainly with influenza A specifically highly pathogenic avian influenza infections and potential zoonotic transmissions. These infections can lead to severe respiratory diseases often linked with high morbidity and mortality in humans. It works in conjunction with other influenza proteins such as neuraminidase contributing to the virus's ability to spread and cause disease in various hosts. Understanding hemagglutinin's role can aid in developing vaccines and therapeutic targets to control and prevent influenza outbreaks.