Abcam, ab283271, Anti-VCP antibody [Z-VCP-10] - Mouse IgG2a (Chimeric)

Size: 20µL / 100µL / 1mL
Mouse Recombinant Monoclonal VCP antibody. Suitable for WB and reacts with Mouse, Rat, Human samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:Z-VCP-10,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
ab283271 is a mouse monoclonal chimeric antibody.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Collaborations
This antibody was developed by the Structural Genomics Consortium and manufactured by Abcam.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The VCP protein also known as p97 or valosin-containing protein is a significant ATPase. It is involved mechanically in a range of cellular activities. VCP has a mass of approximately 97 kDa and is ubiquitously expressed in many tissues. It plays a role in protein homeostasis particularly in the degradation process of misfolded proteins via the ubiquitin-proteasome system. This protein comprises the D1 and D2 ATPase domains that are important for its unfolding activities.
Biological function summary
The VCP protein operates as a vital part of cellular machinery and functions in various complexes. It assists in protein quality control by participating in processes such as ER-associated degradation (ERAD) where it retrotranslocates misfolded proteins from the endoplasmic reticulum for degradation. VCP also contributes to the regulation of endocytosis autophagy and cell cycle control. These functions are important in maintaining cellular integrity.
Pathways
VCP integrates into cellular processes by engaging in essential pathways like the ubiquitin-proteasome system and autophagy. It associates with proteins such as UFD1 and NPL4 in these pathways illustrating its multifaceted role in cellular regulation. VCP's action is closely tied with the p97 protein complexes where it influences protein degradation and recycling thereby controlling protein turnover.
There are findings linking VCP to conditions such as inclusion body myopathy and Paget's disease of bone. Its malfunction due to mutations can trigger these diseases affecting muscle and bone tissues respectively. VCP's connection to other proteins like Parkin and Optineurin in these disorders highlights the protein's relevance in neurodegenerative and skeletal disease pathways emphasizing its pivotal role in maintaining cellular health.