Abcam, ab283609, APC Anti-CD94 antibody [EPR23229-138]

Size: 100µL
Rabbit Recombinant Monoclonal CD94 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23229-138,
Isotype:IgG,
Conjugation:APC,
Excitation/Emission:Ex: 650nm, Em: 660nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD94 also known as killer cell lectin-like receptor subfamily D member 1 (KLRD1) plays a significant mechanical role in the immune system. This protein forms part of a receptor family involved in natural killer (NK) cell function. CD94 typically assembles on the cell surface as a heterodimer often pairing with NKG2 proteins. Weighing approximately 30 kDa CD94 mainly exhibits expression on NK cells and a subset of T cells where it contributes to immune regulation.
Biological function summary
CD94 is essential in recognizing and binding to non-classical MHC class I molecules when it pairs with NKG2 molecules such as NKG2A or NKG2C. This dimer forms a complex receptor which plays an important role in modulating NK cell activity. Through this receptor complex CD94 influences the immune response by either inhibiting or activating NK cells depending on its NKG2 partner. This regulation helps maintain a balanced immune response preventing excessive activation and autoimmunity.
Pathways
CD94 interacts with the signaling pathways related to the immune response. In particular it is involved in the natural killer cell lectin-like receptor signaling pathway. This pathway manages the activation and inhibition of NK cells integrating signals received through various receptors including CD94/NKG2 dimers. Associated proteins like DAP12 may amplify these signals which ultimately influence cytotoxic activities and cytokine production.
CD94 has notable connections with conditions such as cancer and viral infections. For example certain tumors manipulate CD94 expression on NK cells to evade immune surveillance. Additionally alterations in CD94 and its partner molecules like NKG2A have been observed in viral infections possibly affecting how the immune system responds. Understanding CD94's relationship with these diseases can offer insights into potential therapeutic strategies targeting immune regulation.