Abcam, ab284631, Anti-SARS-COV-2 nsp1 antibody [EPR24860-86]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal R1AB antibody. Suitable for ICC/IF, Flow Cyt (Intra), WB and reacts with Transfected cell line - SARS-CoV-2, Recombinant full length protein - SARS-CoV-2 samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24860-86,
Carrier free:No,
Reacts with:SARS-CoV-2,
Applications:Flow Cyt (Intra), WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SARS-CoV-2 nsp1 also known as non-structural protein 1 is a viral protein with a molecular mass of around 19.8 kDa. It is produced by the SARS-CoV-2 virus the agent responsible for the COVID-19 pandemic. Nsp1 is expressed in the cytoplasm of infected host cells. It is important for the virus as it plays a significant role in the regulation of host cell processes making it an interesting target for antiviral research.
Biological function summary
This non-structural protein inhibits host cellular gene expression. Nsp1 disrupts the host's mRNA translation machinery by directly interacting with the ribosomal 40S subunit. This interference enables the virus to suppress the cell's immune response aiding viral replication and assembly. Nsp1 does not form part of a large complex but functions independently to achieve its suppressive effects.
Pathways
Nsp1's function aligns with pathways related to host translation processes and immune evasion tactics. It acts to inhibit the IFN-mediated signaling pathway preventing the usual anti-viral response of the cell. By blocking mRNA binding to the ribosome nsp1 contributes to the shutdown of host protein synthesis which allows virus replication to proceed without host interference. It is closely connected to other viral non-structural proteins that initiate viral replication and assembly within the host.
Nsp1 is directly linked to COVID-19 due to its origin from the SARS-CoV-2 virus. Nsp1's disruption of immune response pathways may contribute to the severity of the disease's impact. It also has indirect relationships with various inflammatory responses due to its immune evasion capability. Through nsp1's action of inhibiting host cell processes it holds potential connections with other proteins involved in immune signaling pathways contributing to investigations into therapeutic interventions against COVID-19.