Abcam, ab284765, Anti-PKC mu/PKD (phospho S916) antibody [EP1494Y] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Monoclonal PKC mu/PKD phospho S916 antibody. Carrier free. Suitable for IP, WB, IHC-P and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP1494Y,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab284765 is the carrier-free version of
ab81218
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PKC mu also known as Protein Kinase D (PKD) is a serine/threonine protein kinase with a notable role in various cellular processes. It is also referred to as PKD 62 due to its molecular mass of approximately 62 kDa. This kinase expresses widely in human tissues with high levels observed in the liver skeletal heart muscle and pancreas. During key cellular actions PKC mu moves between different cellular compartments mediating essential signaling events.
Biological function summary
PKC mu influences several cellular processes including cell proliferation migration and survival. It forms part of a larger protein complex involved in diverse signaling pathways. PKC mu regulates gene expression by affecting various transcription factors. Its activity impacts pathways connected to cell growth and responses to stress demonstrating an essential role in maintaining cellular homeostasis.
Pathways
PKC mu plays an important role in both the MAPK and NF-kB signaling pathways. Through these pathways it interacts with proteins such as Ras and IKK contributing to cell growth and inflammation. PKC mu acts as a bridge allowing signals to be transmitted efficiently ensuring appropriate responses to extracellular stimuli.
PKC mu has been linked to cancer and cardiac hypertrophy. Alterations in PKC mu activity contribute to pathological states due to its involvement in pathways that manage cell growth and stress responses. For instance its overexpression or hyperactivity associates with tumor development and progression. PKC mu's relationship with proteins like Akt in cancer pathways further implicates it in oncogenic processes.