Abcam, ab285279, Salmonella Typhi IgM ELISA Kit

Size: 96Test
Salmonella Typhi IgM ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Salmonella Typhi IgM in Human in Biofluids samples.
Key facts
Detection method:Colorimetric,
Sample types:Plasma, Serum,
Reacts with:Human,
Assay type:Sandwich (quantitative),
Assay Platform:Pre-coated microplate (12 x 8 well strips)

Product details:
Salmonella typhi is the causative agent of typhoid fever a contagious infection of the intestines that affects the whole body. In developing countries, typhoid often occurs in epidemics. Most people in the United States get typhoid as a result of visiting another country where the food or water supply has been contaminated. Symptoms usually start 1 to 3 weeks after exposure to the bacteria. Symptoms include: high fever, headache, sore throat, vomiting, diarrhea, skin rash and weakness. The symptoms may take 2 weeks or more to go away. Typhoid is spread when a person drinks or eats food and water contaminated by human waste (stool or urine) containing Salmonella typhi bacteria. A person who no longer has symptoms may still transmit the bacteria as a carrier. Testing for immunoglobulin G (IgG), IgA, and IgM antilipopolysaccharide (LPS) of Salmonella typhi antibodies by ELISA showed that the levels of all three classes of immunoglobulin anti-LPS of S. typhi were higher in typhoid patients than in healthy or febrile nontyphoidal groups. The ELISA assay (ab285279, E4679) was much more sensitive and specific than any combination of the Widal test, and hence it could be a useful tool for the serologic diagnosis of typhoidal fever with a single blood sample.
This product is manufactured by BioVision, an Abcam company and was previously called E4679 Salmonella Typhi IgM ELISA Kit. E4679-100 is the same size as the 96 test size of ab285279.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Salmonella Typhi IgM refers to the class of immunoglobulin M antibodies produced in response to infection by Salmonella enterica serotype Typhi. This antibody plays an important role in the early immune response to this pathogen. Salmonella Typhi IgM appears in the serum during the acute phase of infection typically within the first week of onset. It does not have alternates names commonly known. The Salmonella Typhi IgM antibodies have a mass of approximately 175 kDa. Most people express the IgM antibodies in response to infection in blood or serum samples which clinicians use for diagnosis.
Biological function summary
These antibodies are essential in the initial defense mechanism against Salmonella infections aiding in the pathogen's clearance from the bloodstream. They do not function as part of a complex but operate independently by binding to the antigens present on the surface of the Salmonella bacteria. This binding triggers processes that lead to the elimination of the bacteria by immune cells. Salmonella Typhi IgM is part of the larger adaptive immune response and directs immune cells to the site of infection.
Pathways
The generation of Salmonella Typhi IgM involves the activation of the humoral immune pathway. This pathway includes key participants like B cells which differentiate into plasma cells to produce these antibodies. Additionally cytokines play a critical role in signaling and amplifying the immune response. The pathway leading to the production of IgM antibodies often interacts with macrophage activation which further contributes to bacterial clearance and immune defense.
Salmonella Typhi IgM is directly associated with Typhoid fever a systemic infection caused by Salmonella enterica serotype Typhi. The presence of these antibodies serves as a marker for early diagnosis and monitoring of the disease's progression. Although primarily linked to Typhoid fever elevated levels of IgM could also indicate other types of non-typhoidal Salmonella infections. Testing for anti-Salmonella IgM is important in differentiating between recent and past infections and it works alongside tests for other antibodies like IgG and proteins like Salmonella antigens for comprehensive diagnosis and disease management.