Abcam, ab285435, BMS-986158

Size: 1mg / 5mg
MW 495.6 Da, Purity >98%. BMS-986158 is a potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor. BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth.
Key facts
CAS number:1800340-40-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:495.6 Da,
Molecular formula:C30H33N5O2,
PubChem:118196485,
Nature:Synthetic,
Solubility:DMSO,
Biochemical name:Bms-986158,
Biological description:BMS-986158 is a potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor. BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth.,
Canonical smiles:CC1=C(N(N=N1)C)C2=CC3=C(C4=C(N3C(C5CCOCC5)C6=CC=CC=C6)C=C(C=C4)C(C)(C)O)N=C2,
Isomeric smiles:CC1=C(N(N=N1)C)C2=CC3=C(C4=C(N3[C@@H](C5CCOCC5)C6=CC=CC=C6)C=C(C=C4)C(C)(C)O)N=C2,
InChi:InChI=1S/C30H33N5O2/c1-19-28(34(4)33-32-19)22-16-26-27(31-18-22)24-11-10-23(30(2,3)36)17-25(24)35(26)29(20-8-6-5-7-9-20)21-12-14-37-15-13-21/h5-11,16-18,21,29,36H,12-15H2,1-4H3/t29-/m1/s1,
InChiKey:KGERZPVQIRYWRK-GDLZYMKVSA-N,
IUPAC Name:2-[3-(3,5-dimethyltriazol-4-yl)-5-[(S)-oxan-4-yl(phenyl)methyl]pyrido[3,2-b]indol-7-yl]propan-2-ol

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2021 BMS-986158. B2021-5 is the same size as the 5 mg size of ab285435.
Protect from air and light.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes