Abcam, ab286170, Anti-GRA5 antibody [TG 17.113]

Size: 100µg / 1mg
Mouse Monoclonal GRA5 antibody. Carrier free. Suitable for WB, IF and reacts with Toxoplasma gondii samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:TG 17.113,
Isotype:IgG1,
Carrier free:Yes,
Reacts with:Toxoplasma gondii,
Applications:WB, IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called A1299 Anti-GRA5 Antibody.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GRA5 protein also known as Dense Granule Protein 5 is a component of the dense granules in Toxoplasma gondii and has an approximate mass of 32 kilodaltons. GRA5 emerges during the intracellular stage of the parasite's life cycle. This protein localizes to the parasitophorous vacuole membrane a specialized compartment formed by the parasite to survive and replicate within host cells. The expression is primarily seen in cells infected by Toxoplasma gondii a widespread obligate intracellular parasite affecting warm-blooded animals.
Biological function summary
GRA5 plays a role in the interaction between Toxoplasma gondii and its host. It participates in the modification of the host cell environment to facilitate parasite persistence and growth. GRA5 is not known to form part of a larger protein complex but works alongside other dense granule proteins to mediate these effects. Understanding GRA5's biological role contributes to comprehending how Toxoplasma manages to thrive within a host by altering host cell functions.
Pathways
Dense granule proteins such as GRA5 are integral to the host-pathogen interaction pathways. GRA5 functions together with other proteins like GRA2 and GRA6 in these interactions. These pathways are critical for the modification and maintenance of the intracellular environment where the pathogen resides. The secretory pathways leading to parasite survival and replication depend on the dense granule proteins' ability to mediate changes in the host cell cytoskeletal and signaling pathways.
GRA5 is implicated in toxoplasmosis a disease caused by infection with Toxoplasma gondii. This condition can lead to severe complications in immunocompromised individuals and during congenital infections. The presence of GRA5 alongside other dense granule proteins like GRA7 has been linked to the immune response modulation in the host influencing disease outcomes. Understanding GRA5's interaction with the host immune system can aid in developing potential therapeutic strategies against toxoplasmosis.