Abcam, ab286911, Anti-SARS2-CoV-2 ORF6 antibody [EPR24849-21]

Size: 40µL / 100µL / 1mL
Rabbit Recombinant Monoclonal NS6 antibody. Suitable for WB and reacts with SARS-CoV-2 samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24849-21,
Isotype:IgG,
Carrier free:No,
Reacts with:SARS-CoV-2,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SARS2-CoV-2 ORF6 also known as ORF6 protein is a small accessory protein of the SARS-CoV-2 virus with a molecular mass around 7 kDa. ORF6 is non-structural and plays an important role in the viral lifecycle. It is expressed in infected host cells alongside other viral proteins. ORF6 has a significant role in manipulating the host's immune response to ensure successful viral replication and spread within the host organism.
Biological function summary
The SARS2-CoV-2 ORF6 protein interacts with host cell proteins to inhibit the host's immune defense. It is known to inhibit the nuclear import of host cell transcription factors like STAT1 and STAT2 effectively dampening the interferon-mediated antiviral response. The protein does not function alone but interacts with other viral components to optimize the virus's evasion strategies.
Pathways
The SARS2-CoV-2 ORF6 protein is involved in the interferon signaling pathway. By impairing this pathway the protein hinders the expression of interferon-stimulated genes that are important for antiviral defense. ORF6 has interactions with host proteins involved in these pathways contributing to an effective immune evasion strategy comparable to other SARS-CoV-2 proteins like NSP1.
The activity of SARS2-CoV-2 ORF6 contributes significantly to the pathogenesis of COVID-19 the disease caused by the SARS-CoV-2 virus. Its function in inhibiting the immune response may lead to severe respiratory symptoms due to uncontrolled viral replication. Connections between ORF6 and other viral proteins like ORF3a have shown a cumulative effect on disease severity highlighting its role in COVID-19 pathology.