Abcam, ab287009, Emetine dihydrochloride hydrate

Size: 50mg / 250mg
MW 571.6 Da, Purity >98%. An alkaloid derived from ipecac root. Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures. It has been found to inhibit endemic human coronaviruses and MERS-CoV in cell culture and cell entry assays.
Key facts
CAS number:7083-71-8,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:571.6 Da,
Molecular formula:C29H44Cl2N2O5,
PubChem:201899,
Nature:Synthetic,
Solubility:Soluble in water to 100 mM,
Biochemical name:Emetine dihydrochloride hydrate,
Biological description:An alkaloid derived from ipecac root. Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures. It has been found to inhibit endemic human coronaviruses and MERS-CoV in cell culture and cell entry assays.,
Canonical smiles:CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.O.Cl.Cl,
Isomeric smiles:CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.O.Cl.Cl,
InChi:InChI=1S/C29H40N2O4.2ClH.H2O/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2/t18-,21-,24+,25-;;;/m0.../s1,
InChiKey:IZTPMTAWOCEKKM-VXMYZLRESA-N,
IUPAC Name:(2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine;hydrate;dihydrochloride

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2339 Emetine dihydrochloride hydrate. B2339-50 is the same size as the 50 mg size of ab287009.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C