Abcam, ab287026, SRT-3025 hydrochloride

Size: 5mg / 25mg
MW 606.2 Da, Purity >98%. SRT-3025 is a potent and selective Sirt1 activator. It inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival. SRT-3025 inhibits RANKL-induced osteoclastogenesis in bone marrow-derived macrophages (BMMs) by activating AMPK and deacetylating RelA/p65 lysine 310, critical for activation of the NF-κB signaling pathway.
Key facts
CAS number:2070015-26-6,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:606.2 Da,
Molecular formula:C31H32ClN5O2S2,
PubChem:118986647,
Nature:Synthetic,
Solubility:Soluble in DMSO to >75 mM,
Biochemical name:SRT3025 HCl,
Biological description:SRT-3025 is a potent and selective Sirt1 activator. It inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival. SRT-3025 inhibits RANKL-induced osteoclastogenesis in bone marrow-derived macrophages (BMMs) by activating AMPK and deacetylating RelA/p65 lysine 310, critical for activation of the NF-κB signaling pathway.,
Canonical smiles:COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=C(S4)N=CC(=C5)CN6CCCC6.Cl,
InChi:InChI=1S/C31H31N5O2S2.ClH/c1-38-17-9-14-26-27(35-29(39-26)22-10-3-2-4-11-22)28(37)33-24-13-6-5-12-23(24)30-34-25-18-21(19-32-31(25)40-30)20-36-15-7-8-16-36;/h2-6,10-13,18-19H,7-9,14-17,20H2,1H3,(H,33,37);1H,
InChiKey:LGRBDTOIPNDWMN-UHFFFAOYSA-N,
IUPAC Name:5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(pyrrolidin-1-ylmethyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]-1,3-thiazole-4-carboxamide;hydrochloride

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2376 SRT-3025 hydrochloride. B2376-25 is the same size as the 25 mg size of ab287026.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C