Abcam, ab287122, LF3

Size: 5mg
MW 416.6 Da, Purity >98%. A potent inhibitor of canonical Wnt signaling pathway (IC 50 < 2 μM ). It can disrupt the interaction between catenin and TCF4. LF3 blocks the expression of a series of Wnt target genes in Wnt-addicted colon cancer cells. It inhibits proliferation of Wnt-addicted colon cancer cells through induction of cell-cycle arrest and also inhibits self-renewal capacity of cancer stem cells (CSCs).
Key facts
CAS number:664969-54-4,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:416.6 Da,
Molecular formula:C20H24N4O2S2,
PubChem:1213452,
Nature:Synthetic,
Solubility:>50 mg/ml DMSO,
Biochemical name:4-[(2E)-3-phenylprop-2-en-1-yl]-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide,
Biological description:A potent inhibitor of canonical Wnt signaling pathway (IC50 < 2 μM ). It can disrupt the interaction between catenin and TCF4. LF3 blocks the expression of a series of Wnt target genes in Wnt-addicted colon cancer cells. It inhibits proliferation of Wnt-addicted colon cancer cells through induction of cell-cycle arrest and also inhibits self-renewal capacity of cancer stem cells (CSCs).,
Canonical smiles:C1CN(CCN1CC=CC2=CC=CC=C2)C(=S)NC3=CC=C(C=C3)S(=O)(=O)N,
Isomeric smiles:C1CN(CCN1C/C=C/C2=CC=CC=C2)C(=S)NC3=CC=C(C=C3)S(=O)(=O)N,
InChi:InChI=1S/C20H24N4O2S2/c21-28(25,26)19-10-8-18(9-11-19)22-20(27)24-15-13-23(14-16-24)12-4-7-17-5-2-1-3-6-17/h1-11H,12-16H2,(H,22,27)(H2,21,25,26)/b7-4+,
InChiKey:ZUQIFHLBPBLRRM-QPJJXVBHSA-N,
IUPAC Name:4-[(E)-3-phenylprop-2-enyl]-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2644 LF3. B2644-25 is the same size as the 25 mg size of ab287122.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark