Abcam, ab287126, NSC-617145

Size: 5mg
MW 400 Da, Purity >98%. An inhibitor of Werner syndrome helicase (WRN) (IC 50 = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only displaying 7% inhibition of RECQ1 at a concentration of 5 μM. It acts synergistically with Mitomycin C to induce double-strand breaks and chromosomal abnormalities in vitro .
Key facts
CAS number:203115-63-3,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:400 Da,
Molecular formula:C13H10Cl4N2O4,
PubChem:357621,
Nature:Synthetic,
Solubility:~8 mg/ml DMSO,
Biochemical name:3,4-Dichloro-1-[3-(3,4-dichloro-2,5-dioxopyrrol-1-yl)-2,2-dimethylpropyl]pyrrole-2,5-dione,
Biological description:An inhibitor of Werner syndrome helicase (WRN) (IC50 = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only displaying 7% inhibition of RECQ1 at a concentration of 5 μM. It acts synergistically with Mitomycin C to induce double-strand breaks and chromosomal abnormalities in vitro.,
Canonical smiles:CC(C)(CN1C(=O)C(=C(C1=O)Cl)Cl)CN2C(=O)C(=C(C2=O)Cl)Cl,
InChi:InChI=1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3,
InChiKey:PCOXPBOKDABARQ-UHFFFAOYSA-N,
IUPAC Name:3,4-dichloro-1-[3-(3,4-dichloro-2,5-dioxopyrrol-1-yl)-2,2-dimethylpropyl]pyrrole-2,5-dione

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2664 NSC-617145. B2664-25 is the same size as the 25 mg size of ab287126.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark