Abcam, ab28751, Anti-TRAK1 antibody

Size: 100µg
Goat Polyclonal TRAK1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TRAK1 aa 900 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TRAK1 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9UPV9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This antibody was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 0.5% BSA, 0.5% Tris buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRAK1 also known as trafficking kinesin-binding protein 1 is a motor protein adaptor with a critical role in intracellular transport. It has an approximate mass of 95 kDa. TRAK1 facilitates the interaction between kinesin motors and their cargo enabling proper transport along microtubules. It expresses widely though high levels can be found in the nervous system. TRAK1 contains specific domains that bind to both kinesin motors and microtubules allowing it to effectively guide intracellular movement.
Biological function summary
TRAK1 influences mitochondrial trafficking within neurons. It is part of a complex with other motor proteins such as kinesin and dynein that manage mitochondria distribution. By regulating this process TRAK1 affects energy supply critical for neuron function. Proper mitochondrial distribution holds importance for neuron survival and health and TRAK1 impacts synaptic plasticity through this mechanism.
Pathways
TRAK1 plays an essential part in the neuronal trafficking pathways. It works closely with the mitochondria transport pathway along with proteins like Miro1 and Miro2 to ensure mitochondrial movement. This ensures proper placement of mitochondria where energy demand is highest. TRAK1's role in the axonal transport pathway also ties it to neuron structure maintenance and repair aligning it closely with kinesin-related pathways.
Aberrations in TRAK1 function have links to neurodegenerative illnesses like Alzheimer's disease. Mutations or dysfunctions in TRAK1 may lead to improper mitochondrial distribution contributing to neuronal injury. It also has a connection to Charcot-Marie-Tooth disease where disruptions in mitochondrial function are important. In these contexts TRAK1 relates to other proteins such as Miro1 and MFN2 impacting their regulation and affecting disease progression.