Abcam, ab2904, Anti-Angiostatin antibody

Size: 100µg
Rabbit Polyclonal Plasminogen antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse samples. Cited in 16 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Angiostatin a fragment derived from plasminogen acts critically in inhibiting angiogenesis. It has a molecular mass of approximately 38 kDa. Angiostatin primarily derives from proteolytic cleavage of plasminogen within the vascular system. Expression of angiostatin occurs in various tissues but it is predominantly observed around tumor sites where it exerts its anti-angiogenic effects.
Biological function summary
Angiostatin functions to inhibit the proliferation and migration of endothelial cells thereby blocking new blood vessel formation. It achieves this by binding to ATP synthase on the surface of endothelial cells. This protein operates as an isolated entity and does not typically form part of a larger complex. Angiostatin’s activity is essential in controlling physiological processes requiring reduced blood vessel development.
Pathways
Angiostatin participates actively in the angiogenesis pathway interacting with factors like vascular endothelial growth factor (VEGF). It opposes pro-angiogenic signals by suppressing these pathways reducing the available nutrients to target tissues such as tumors. Angiostatin's role in the lysine-binding pathway also connects it to proteins like plasmin influencing fibrinolytic activity.
Angiostatin associates strongly with cancer and ocular diseases like diabetic retinopathy. Its inhibitory effect on angiogenesis restricts the blood supply to tumors aiding in cancer treatment. In cancer angiostatin interacts with plasminogen activator inhibitor-1 (PAI-1) to modulate plasminogen activity. In ocular diseases angiostatin’s impact on abnormal blood vessel growth contributes to therapeutic strategies to manage these conditions.