Abcam, ab290655, Anti-Alpha-synuclein, isoform 98 and 126 antibody [EPR25117-81] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Alpha-synuclein antibody. Carrier free. Suitable for ICC, WB, IHC-P, Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25117-81,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WB, Flow Cyt (Intra), ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Alpha-synuclein, isoform 98 and 126.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha-synuclein isoform 98 and 126 also known as SNCA plays a mechanical role in neurons. This protein is an important part of the nerve cell cytoplasm distributed mainly in presynaptic terminals of the brain. With a molecular weight of about 14 kDa SNCA functions in both soluble and membrane-bound forms. Expression of alpha-synuclein occurs in the central nervous system but it is seen in some peripheral tissues too.
Biological function summary
The protein contributes to the regulation of synaptic vesicle trafficking and neurotransmitter release. As part of a complex alpha-synuclein interacts with a variety of other synaptic proteins affecting vesicle mobility and ensuring efficient synaptic transmission. It influences neuronal plasticity and survival supporting nervous system function. Though still under investigation these functions indicate a regulatory role in maintaining neural communication.
Pathways
One can see the involvement of alpha-synuclein in the dopamine and calcium signaling pathways. These pathways impact synaptic transmission with overlaps including proteins like LRRK2 and parkin. Alpha-synuclein's regulation of cellular transport processes connects these pathways impacting their overall function by modulating synaptic vesicle dynamics.
Alpha-synuclein is linked to Parkinson's Disease and Lewy Body Dementia. These neurodegenerative disorders show abnormal accumulation of the protein. Interactions between SNCA and others such as tau protein and amyloid precursor protein lead to pathological changes. Understanding these interactions provides insight into how alpha-synuclein contributes to disease mechanisms making it an important focus for therapeutic research.