Abcam, ab290732, Anti-M Cadherin antibody [EPR25401-63]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal M Cadherin antibody. Suitable for IHC-P and reacts with Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25401-63,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Mouse,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
M-Cadherin also known as CDH15 is a member of the cadherin superfamily. This calcium-dependent cell adhesion molecule is approximately 100 kilodaltons in mass. M-Cadherin is expressed mostly in muscle tissues where it plays a role in cell recognition and connection processes. The presence of this protein on the cell surface helps in forming intercellular junctions contributing to the stabilization of cell interactions which are essential for developmental and repair functions in muscle cells.
Biological function summary
M-Cadherin facilitates cell-cell adhesion which is vital for the proper alignment of muscle cells during development and repair. This protein is a critical component of the adherens junction complex. During muscle regeneration M-Cadherin helps satellite cells to adhere to existing muscle fibers promoting the fusion needed for effective muscle repair. It operates alongside other proteins including β-catenin and α-catenin which link cadherins to the actin cytoskeleton reinforcing structural integrity.
Pathways
Different cellular processes involve M-Cadherin playing a role in the Wnt signaling and Notch signaling pathways. Wnt signaling is significant in muscle development and regeneration. M-Cadherin interacts with β-catenin in this pathway balancing the regulation of cellular adhesion and signaling events. In the Notch signaling pathway M-Cadherin influences satellite cell activation and proliferation helping maintain muscle stem cell populations which are important under conditions requiring muscle repair.
M-Cadherin has implications in muscle-related conditions such as muscular dystrophy and muscle degeneration. The protein's malfunction can result in impaired cell adhesion leading to defects in muscle repair mechanisms. In muscular dystrophy M-Cadherin-related disruptions are observed often together with abnormal β-catenin interactions. These disruptions contribute to inadequate muscle regeneration and muscular weakness underlining M-Cadherin's importance in maintaining muscle health.