Abcam, ab300053, Anti-PTGES2/Gbf1 antibody [EPR25169-3] (BSA and Azide free)

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal PTGES2/Gbf1 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25169-3,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTGES2 also known as Gbf1 is a member of the prostaglandin E synthase family and functions as an enzyme involved in the conversion of PGH2 to PGE2 an essential step in prostaglandin biosynthesis. The protein has an approximate mass of 40 kDa. PTGES2 is expressed across various tissues with higher levels observed in the brain kidney and liver. The enzyme operates optimally in the presence of reduced glutathione which is necessary for its activity.
Biological function summary
PTGES2 plays an important role in the synthesis of prostaglandins which are lipid compounds that perform critical functions in inflammation and other cellular processes. As part of the prostaglandin synthesis pathway PTGES2 interacts cooperatively with other enzymes such as cyclooxygenase-2 (COX-2) to produce PGE2. PGE2 is significant for regulating immune responses and maintaining homeostasis. Disruptions in prostaglandin production can lead to various inflammatory disorders.
Pathways
PTGES2 is integral to the arachidonic acid metabolic pathway where it acts in unison with COX-2 and other enzymes to convert arachidonic acid into bioactive prostaglandins. Specifically its role in the PGE2 synthesis pathway is well-documented which ties it closely to proteins involved in eicosanoid synthesis. PGE2 the product of this pathway modulates both pain and inflammation showing how PTGES2 impacts physiological processes beyond its enzymatic function.
PTGES2 has been linked to inflammatory conditions such as rheumatoid arthritis and cancer. Its activity correlates with increased levels of PGE2 a molecule known for promoting inflammation and tumorigenesis. Associations with COX-2 have been studied extensively in the context of cancer especially in relation to its impact on cellular proliferation and immune evasion. As our understanding of PTGES2 continues to evolve its potential as a therapeutic target for inflammatory and neoplastic diseases is being actively investigated.