Abcam, ab300455, Anti-Sodium/calcium exchanger 2 antibody [EPR25106-37]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Sodium/calcium exchanger 2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25106-37,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human, Rat,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Sodium/calcium exchanger 2 (NCX2 or SLC8A2) is a protein that functions in the transportation of sodium (Na+) and calcium (Ca2+) ions across the plasma membrane. It operates by exchanging three sodium ions from the extracellular space with one calcium ion from the intracellular space effectively managing cellular calcium homeostasis. The protein has an approximate mass of 120 kDa. NCX2 is primarily expressed in the brain with significant levels in specific regions such as the hippocampus and cortex. This expression pattern implies a role in neural functions and signaling.
Biological function summary
The NCX2 protein plays a significant part in maintaining calcium ion concentration in neurons which is important for processes such as synaptic activity and plasticity. It forms part of a larger complex of membrane proteins interacting with other ion channels and exchangers to regulate the ionic balance and cellular responses. By extruding calcium NCX2 helps in preventing calcium overload that could lead to neuronal damage.
Pathways
The NCX2 protein is involved in calcium signaling and neurodegenerative pathways. In the calcium signaling pathway NCX2 interacts with other proteins like the L-type calcium channels modulating the influx and efflux of ions to sustain appropriate cellular functions. In neurodegenerative pathways NCX2’s role in calcium efflux associates it with other proteins that govern neuronal survival and apoptosis highlighting its involvement in cell death processes when dysregulated.
The malfunctioning of NCX2 is linked to certain neurodegenerative conditions such as Alzheimer’s disease and epilepsy. Research shows that disrupted NCX2 activity can lead to abnormal calcium accumulation contributing to neuronal degeneration and seizures. NCX2 is connected to the amyloid precursor protein (APP) through Alzheimer’s disease where excessive calcium can accelerate neurotoxic amyloid beta formation. In epilepsy altered NCX2 function can lead to excessive excitatory transmission due to an imbalance in calcium handling.