Abcam, ab300481, Anti-SAP97 antibody [EPR26467-123]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal SAP97 antibody. Suitable for IP, IHC-Fr, IHC-P, WB and reacts with Mouse, Human, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26467-123,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-Fr, IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAP97 also known as Synapse-associated protein 97 or DLG1 is a member of the membrane-associated guanylate kinase (MAGUK) family. It has a molecular mass of approximately 97 kDa. This protein is well-expressed in several tissues with high levels observed within the brain and cardiac muscles. SAP97 plays an essential role in organizing synaptic proteins and maintaining cell polarity by aiding in the trafficking and localization of certain ion channels and receptors across the plasma membrane.
Biological function summary
The function of SAP97 is closely linked to synaptic plasticity and signal transduction. This protein forms part of larger protein complexes that include ion channels and receptors helping regulate the transmission of signals between neurons. In the brain SAP97 facilitates the clustering of neurotransmitter receptors at synapses including AMPA receptors which are vital for excitatory synaptic transmission. Its role extends to modulating the structural organization and functional regulation of these protein complexes at synaptic junctions.
Pathways
SAP97 is involved in key signaling processes particularly the glutamatergic synapse pathway where it influences the trafficking and surface expression of glutamate receptors. It interacts with other MAGUK family members like PSD-95 to regulate the assembly of the postsynaptic density. This protein also plays a role in the cardiac signaling cascade particularly in interactions involving potassium channels impacting the cardiac action potential.
SAP97 has associations with neurological and cardiac conditions. Abnormal expression or mutation in SAP97 can contribute to disorders such as schizophrenia and arrhythmias. In schizophrenia disruption in SAP97 function affects synaptic communication with related proteins like PSD-95 implicated in the disease's pathology. In cardiac arrhythmias the misregulation of SAP97 interaction with ion channels might result in altered cardiac electrical activity impacting the role of proteins such as Kv4.2 in the heart's electrophysiological stability.