Abcam, ab302522, Anti-XCL1+XCL2 antibody [EPR26181-30]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal XCL1 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IP and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26181-30,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, Flow Cyt (Intra), IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
XCL1 and XCL2 also known as lymphotactin or ATAC are small proteins from the chemokine family. These proteins serve as chemotactic agents guiding the migration of immune cells to sites of inflammation or injury. XCL1 and XCL2 have an approximate molecular mass of 10 kDa. They are mainly expressed in activated T cells and natural killer (NK) cells. Their expression is most prominent in tissues involved in immune responses including spleen and lymph nodes.
Biological function summary
XCL1 and XCL2 engage in guiding lymphocytes to the site where they are needed such as inflamed or infected tissue areas. They do not form part of larger protein complexes but function independently to attract specific types of immune cells. By binding to their receptor XCR1 on dendritic cells and other immune cells they instigate responses that are critical for initiating and regulating immune surveillance and responses.
Pathways
XCL1 and XCL2 are involved in the chemokine signaling pathway that orchestrates the movement and position of immune cells within tissues. They interact with proteins such as the XCR1 receptor on cell surfaces triggering signaling cascades that facilitate inflammatory responses. The chemokine signaling pathway is closely linked with other immune pathways such as the cytokine-cytokine receptor interaction pathway allowing cross-talk and intervention of various immune mediators.
XCL1 and XCL2 have been linked to autoimmune conditions like rheumatoid arthritis and some cancer types where inflammation plays a significant role. During chronic inflammation their dysregulated expression can lead to exacerbated immune responses contributing to disease pathogenesis. The interaction with XCR1 and its presence on dendritic cells is important for understanding their involvement in such disorders. Additionally their connection to other inflammatory cytokines can amplify the inflammatory cascade impacting disease progression and patient outcomes.