Abcam, ab302787, Anti-Nav1.6/SCN8A antibody [EPR25137-45] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal SCN8A antibody. Carrier free. Suitable for WB, IHC-P, IHC-Fr, IP and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25137-45,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, IHC-Fr, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab302787 is a carrier free version of
ab302776
ab302786
does not react in: IHC-P with human samples; ICC/IF with human, mouse, and rat species; intracellular flow cytometry with mouse and rat samples.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Nav1.6 also known as SCN8A is a voltage-gated sodium channel with a molecular mass of approximately 260 kDa. It is well-known for its significant role in propagating action potentials in neurons. Nav1.6 is highly expressed in the central nervous system specifically in the nodes of Ranvier and axon initial segments of neurons. This channel allows the influx of sodium ions which is critical for the rapid depolarization phase of action potentials facilitating nerve signal transmission.
Biological function summary
Nav1.6 impacts neuronal excitability and firing by controlling sodium ion flow across the nerve cell membrane. It forms an integral part of the channel complex that ensures proper electrical signaling within neurons. It largely contributes to high-frequency firing and sustained repetitive firing of specific neurons which is essential for normal brain function. Alterations in Nav1.6 function can lead to abnormal electrical activity in the nervous system impacting overall neuronal communication.
Pathways
Nav1.6 participates significantly in the action potential propagation pathway. It plays a role alongside other sodium channels such as Nav1.1 and Nav1.2 to maintain the intricate balance of excitatory signals. Nav1.6 is also involved in signaling cascades that affect synaptic transmission and plasticity. In these pathways Nav1.6 interacts indirectly with various ion channels and proteins which collectively modulate neuronal excitability and plasticity important for processes like learning and memory.
Disrupted Nav1.6 function associates with epileptic encephalopathy and ataxia. Mutations in the SCN8A gene that encodes for Nav1.6 can cause abnormal channel activity leading to hyperexcitability of neurons and seizure disorders. Additionally the improper functioning of Nav1.6 links to disorders featuring motor and cognitive impairments. In these contexts Nav1.6 is commonly discussed with proteins like Nav1.2 which also contribute to pathological neuronal excitability highlighting the interconnectedness of ion channel dynamics in neurological diseases.