Abcam, ab303536, Anti-PPM1H antibody [EPR26028-53]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal PPM1H antibody. Suitable for WB, IHC-P, IHC-Fr, IP and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26028-53,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-Fr, WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Unsuitable for human IP

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein phosphatase Mg2+/Mn2+ dependent 1H (PPM1H) is an enzyme that regulates cellular functions by removing phosphate groups from specific proteins. Known also as protein phosphatase 1H it has a molecular mass of approximately 55 kDa. It is expressed mainly in the brain but also in other tissues such as heart and kidney. PPM1H plays a role in intracellular signal transduction by dephosphorylating target proteins involved in cellular processes.
Biological function summary
PPM1H modulates cellular signaling pathways impacting various physiological processes. It acts independently and does not form part of any known larger protein complex. Within cells PPM1H may interact with substrates involved in important cellular functions such as growth differentiation and apoptosis. Researchers propose that it acts as a regulatory phosphatase influencing cell cycle and stress response at a cellular level.
Pathways
PPM1H is involved in signaling pathways like the TGF-beta and MAPK pathways. In these pathways it interacts with proteins such as SMAD2 and MAPK modulating their activity through dephosphorylation. The TGF-beta pathway plays an important role in regulating cell growth and differentiation while the MAPK pathway is essential for transmitting extracellular signals to cellular responses including gene expression.
PPM1H has been implicated in nervous system disorders like Parkinson's disease and Alzheimer's disease. Studies suggest that altered PPM1H function can disrupt signaling pathways leading to neuronal degeneration. In Parkinson's disease PPM1H's connection to LRRK2 a protein kinase mutated in some hereditary cases shows potential implications in disease progression due to regulatory interactions.