Abcam, ab30483, Anti-Integrin alpha 2+beta 1 antibody [16B4]

Size: 100µg
Mouse Monoclonal Integrin alpha 2 antibody. Suitable for Flow Cyt, ICC/IF and reacts with Human samples. Cited in 14 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:16B4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
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Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-ab30483 was purified from tissue culture supernatant, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 6.97% L-Arginine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin alpha 2+beta 1 also known as integrin a2b1 or alpha 2 beta 1 integrin is a heterodimeric cell surface receptor with a mass of approximately 150 kDa. It is expressed on a variety of cells including epithelial and endothelial cells as well as platelets. The primary role of integrin alpha 2+beta 1 involves mediating cell adhesion to collagen a major component of the extracellular matrix. This interaction is critical for maintaining tissue architecture and integrity. The receptor's structure allows it to bind to specific ligands facilitating cell communication and signal transduction across the cell membrane.
Biological function summary
Integrin alpha 2+beta 1 contributes to processes such as cell migration proliferation and differentiation. This integrin functions as part of a larger integrin family complex which includes related integrins like alpha 1 beta 1 and alpha 6 beta 4. These integrins share similarities in structure and function but have distinct binding specificities and tissue distributions. The presence of integrin alpha 2+beta 1 in various tissues indicates its role in tissue-specific cellular activities underlying its contribution to diverse biological functions.
Pathways
Integrin alpha 2+beta 1 is involved in the MAPK/ERK and PI3K/AKT signaling pathways. These pathways are essential for transmitting signals from the extracellular environment to the cell nucleus influencing gene expression and cellular responses. The integrin interacts with proteins such as focal adhesion kinase (FAK) and Src family kinases which are important for initiating downstream signaling events. The interaction of integrin alpha 2+beta 1 within these pathways highlights its role in regulating cellular responses to environmental changes and stresses.
Integrin alpha 2+beta 1 has been linked to cancer metastasis and fibrosis. Its role in promoting cell adhesion and migration is critical in the progression of these diseases. In cancer integrin alpha 2+beta 1 supports tumor cell invasion through the basement membrane by interacting with proteins like matrix metalloproteinases. Fibrosis involves excessive tissue scarring where the integrin contributes to the proliferation of myofibroblasts and deposition of extracellular matrix. Understanding the involvement of integrin alpha 2+beta 1 in these conditions could lead to potential therapeutic targets for intervention.