Abcam, ab30488, FITC Anti-Integrin alpha 3 antibody [17C6]

Size: 50µg
Mouse Monoclonal Integrin alpha 3 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing ITGA3 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:17C6,
Isotype:IgG1,
Conjugation:FITC,
Excitation/Emission:Ex: 495nm, Em: 519nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing ITGA3 protein. The exact immunogen used to generate this antibody is proprietary information.P26006,
Specificity:ab30488 recognises CD49c, a 150kD cell surface antigen which is also known as the alpha-3 integrin and as VLA-3. CD49c is expressed by most cell types including T and B lymphocytes.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin alpha 3 also known as ITGA3 or alpha 3 is a protein that plays an important role in cell adhesion and signaling. It forms complexes with other integrins to mediate interactions between cells and the extracellular matrix. Integrin alpha 3 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. This protein is primarily expressed in epithelial tissues including the skin kidneys and respiratory tract.
Biological function summary
Integrin alpha 3 functions as a cell surface receptor that helps regulate cell migration proliferation and differentiation. It is a part of the alpha-3-beta-1 integrin complex which interacts with extracellular proteins like laminin-5 and collagen. This interaction facilitates the transmission of signals from the outside to the inside of the cell affecting various cellular responses and activities.
Pathways
Integrin alpha 3 plays a significant role in the cell signaling and communication pathways. It is involved in the pathways like focal adhesion and MAPK signaling. In these pathways integrin alpha 3 interacts with other proteins such as paxillin and FAK (focal adhesion kinase) which are critical for the downstream signaling that regulates cell shape and movement.
Integrin alpha 3 is linked to conditions like skin blistering diseases and cancers particularly those affecting the epithelial tissues. Alterations in integrin alpha 3 expression or function can disturb cell adhesion leading to diseases like epidermolysis bullosa. Additionally in cancer integrin alpha 3 often collaborates with proteins like MMP-9 to promote tumor invasion and metastasis.