Abcam, ab30562, Anti-Eph receptor B1/NET (phospho Y317) antibody

Size: 100µL
Rabbit Polyclonal Eph receptor B2 phospho Y317 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Chicken EPHB2 phospho Y317.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Chicken EPHB2 phospho Y317. The exact immunogen used to generate this antibody is proprietary information.P28693,
Specificity:ab30562 recognises EphB1 (phospho Y317).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Prepared from rabbit serum by affinity purification via sequential chromatography on phospho and dephosphopeptide affinity columns., Storage buffer-pH: 7.5Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Eph receptor B1 also called NET or B1 receptor is a member of the Eph receptor family. It plays roles in various cellular processes through its mechanical action as a receptor tyrosine kinase. The Eph receptor B1 primarily mediates signaling by binding to ephrin-B ligands. This interaction triggers bidirectional signaling between cells influencing cell positioning shape and movement. Eph receptor B1 which has a molecular weight of approximately 120 kDa expresses highly in tissues like the brain and testes suggesting its importance in these organ systems.
Biological function summary
Eph receptor B1 affects cell adhesion migration and tissue patterning by participating in complex networks. These receptors and their ephrin ligands form a complex that enables cross-communication between adjacent cells. Eph receptor B1 modulates processes like synapse formation in the brain thereby impacting neural development and connectivity. As a result it plays a role in maintaining cellular architecture and function in a specific tissue context.
Pathways
Eph receptor B1 is an integral part of the Eph/Ephrin signaling pathway which influences developmental processes and cellular interactions. In this pathway Eph receptor B1 works alongside proteins like ephrin-B to mediate cell-cell communication and signal transduction. This pathway has implications for the formation and remodeling of blood vessels suggesting further links to the angiogenesis pathway. Such pathways are important for translating external signals into cellular responses shaping the biology of tissues and organs.
Alterations in Eph receptor B1 function can relate to conditions such as cancer and neurological disorders. In cancers aberrant Eph receptor B1 signaling can promote tumor growth and metastasis with the receptor often associating with proteins like ephrin-B to drive tumorigenic processes. In the context of neurological diseases like Alzheimer's disease disruptions in Eph receptor B1 signaling can affect neural connectivity and function illustrating its role in maintaining brain health. Understanding these connections helps clarify the receptor's impact on disease development and progression.