Abcam, ab306543, PE Anti-CXCR1 antibody [EPR23700-70]

Size: 100µL
Rabbit Recombinant Monoclonal CXCR1 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23700-70,
Isotype:IgG,
Conjugation:PE,
Excitation/Emission:Ex: 480;565nm, Em: 578nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CXCR1 also known as IL-8 receptor A is a G-protein-coupled receptor with a mass of approximately 40 kDa. It is primarily located on the surface of neutrophils a type of white blood cell and various other immune cells. CXCR1 recognizes and binds interleukin-8 (IL-8) an important chemokine that guides immune cells to sites of inflammation or infection. The binding of IL-8 to CXCR1 induces conformational changes activating intracellular signaling pathways which result in cellular responses like chemotaxis and phagocytosis.
Biological function summary
CXCR1 plays an important role in the immune system's response to infection and inflammation. It binds to IL-8 as part of the body's inflammatory response recruiting neutrophils and other immune cells to infected or damaged tissues. This receptor is not known to be part of a larger protein complex but it interacts with various signaling molecules within the cell to modulate cellular responses. The proper functioning of CXCR1 is essential for a balanced immune response and effective pathogen clearance.
Pathways
CXCR1 is an important component of the chemokine signaling pathway which is essential for the migration of immune cells to sites of inflammation. It also plays a critical role in the NF-kB signaling pathway which is involved in immune response and inflammation. Through these pathways CXCR1 interacts with other proteins like CXCR2 and IL-8 helping coordinate the movement and activation of immune cells necessary for defending against pathogens.
CXCR1 is linked to inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis. It is involved in the excessive recruitment and activation of neutrophils contributing to tissue damage and disease progression. CXCR1 is also connected to CXCR2 in the context of these diseases as both receptors bind IL-8 and mediate similar inflammatory responses. Understanding CXCR1's role in these conditions can provide insights into developing targeted therapies aimed at reducing inflammation and disease severity.