Abcam, ab306586, Anti-SCN4A antibody [EPR24138-282] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal SCN4A antibody. Carrier free. Suitable for IHC-Fr and reacts with Rat, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24138-282,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat,
Applications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SCN4A gene encodes the Nav1.4 protein also known as the sodium channel voltage-gated type IV alpha subunit. Nav1.4 is a voltage-gated sodium channel with a molecular weight around 250 kDa. It mainly facilitates the rapid influx of sodium ions into skeletal muscle cells which is important for the initiation and conduction of action potentials. Expression of Nav1.4 is strong in skeletal muscle tissues playing an important role in muscle excitability and contraction. It serves as a pivotal point in the regulation of skeletal muscle function.
Biological function summary
Nav1.4 is essential in generating and propagating action potentials necessary for muscle contraction. This protein functions as part of a complex that includes beta subunits that help modulate its properties. The precise gating and ion permeability of Nav1.4 are important for proper muscle responsiveness. Nav1.4's activity ensures proper muscle tone and responsiveness to neurological inputs impacting motor function and muscle reflexes directly.
Pathways
Nav1.4 is integral to pathways involved in action potential propagation and muscle contraction. It forms part of the larger excitable membrane network that includes calcium channels such as Cav1.1 and proteins like ryanodine receptors (RYRs) which participate in muscle excitation-contraction coupling. Nav1.4 has a synergistic relationship with these proteins enabling the effective transmission of electrical signals that trigger muscle contraction in response to stimuli.
Alterations in SCN4A can lead to conditions like Hyperkalemic Periodic Paralysis and Paramyotonia Congenita. Mutations affecting Nav1.4 disrupt normal muscle excitability leading to symptoms such as muscle weakness and temporary paralysis. There are associations between these disorders and other ion channels like Kir2.1 which can compound effects on membrane excitability. Understanding the role of Nav1.4 in these diseases aids in developing therapeutic strategies for muscle channelopathies.