Abcam, ab306589, Anti-ANK-3 antibody [EPR26551-66]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal ANK-3 antibody. Suitable for IHC-Fr, IHC-P, WB and reacts with Rat, Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26551-66,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-Fr, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ANK-3 also known as ankyrin-G has a significant role in maintaining the structural integrity and function of cells. It is a cytoskeletal protein with a molecular weight approximately 220 kDa. ANK-3 is expressed in a wide variety of tissues with high expression in the brain heart and skeletal muscle. It links integral membrane proteins to the underlying spectrin-actin cytoskeleton stabilizing the cellular membrane and organizing membrane domains.
Biological function summary
The interaction of ANK-3 with various proteins contributes to cellular activities. ANK-3 binds to key molecules like ion channels and cell adhesion molecules making it an integral part of the cell membrane-cytoskeleton interface. It is a member of the ankyrin family which includes ANK and ANK-106 providing different isoforms like ANK-3 isoforms that contribute to its diverse functional roles. ANK-3 associates with specific complexes facilitating the localization of nodes of Ranvier in axons and maintaining polarized distribution of channels in neurons.
Pathways
ANK-3 serves a major function in the neurobiological and cardiac pathways. It plays a role in the regulation of action potentials in neurons through its interaction with ion channels and is essential in cardiac muscle function by associating with proteins involved in heart rhythm regulation. ANK-3 through these pathways exhibits functional relationships with proteins such as ANK-2 and 2a8 which further influence cellular excitability and signaling.
Disruptions in ANK-3 function associate with neuropsychiatric disorders and cardiac arrhythmias. ANK-3 dysfunction has been implicated in bipolar disorder where genetic variations may affect its molecular interactions leading to altered neuronal signaling. In cardiac contexts improper expression or mutations of ANK-3 can contribute to arrhythmogenic disorders sometimes in coordination with proteins such as n106 and other ankyrins impacting cardiac stability.